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Deciphering Mechanisms of Respiratory Fetal-to-Neonatal Transition in Very Preterm Infants
Gaertner, V.D., et al. American Journal for Respiratory and Critical Care Medicine. 2023
Over 10,000 breaths from 33 preterm infants (26-32 weeks GA) were analyzed with Sentec EIT to characterize breathing patterns during the transition from fetal to neonatal life: tidal breathing, braking, and holding. Findings revealed that holding breaths contributed most to early lung aeration.
Initial Observations on the Effect of Repeated Surfactant Dose on Lung Volume and Ventilation in Neonatal Respiratory Distress Syndrome
Kallio, M., et al. Neonatology. 2019
This study, part of the CRADL multicenter trial, investigated the effects of repeated surfactant dosing on regional ventilation and lung volumes in preterm infants. EIT revealed that repeated surfactant dose during invasive ventilation improved oxygenation without measurable changes in EELZ.
Transmission of Oscillatory Volumes into the Preterm Lung during Noninvasive High-Frequency Ventilation
Gaertner, V.D., et al. American Journal for Respiratory and Critical Care Medicine. 2021
This randomized crossover trial of 30 infants utilizing EIT provided the first evidence that nHFOV oscillations were effectively transmitted to the lungs, with a preference for the right and non-gravity-dependent lung regions.
Lung Volume Changes in Stable Preterm Infants Weaned From Nasal CPAP to High Flow
Büchler, V.L., et al. CHEST Pulmonary. 2024.
Monitoring preterm infants with EIT illustrated that the transition from nCPAP to high flow is likely to result in a gradual reduction in EELV, accompanied by physiological responses in heart rate and oxygenation.
Lung Recruitment Assessed by Electrical Impedance Tomography (RECRUIT): A Multicenter Study of COVID-19 Acute Respiratory Distress Syndrome
Jonkman, A.H., et al. American Journal for Respiratory and Critical Care Medicine. 2023.
In this multicenter study, EIT allowed personalized PEEP setting as a compromise between recruitability and overdistension (crossing point method) in 108 COVID-19 ARDS patients.
Personalized Positive End-Expiratory Pressure in Acute Respiratory Distress Syndrome: Comparison Between Optimal Distribution of Regional Ventilation and Positive Transpulmonary Pressure
Scaramuzzo, G., et al. Critical Care Medicine. 2020.
This study compared two methods of selecting personalized PEEP in ARDS patients: EIT based on the total amount of hypoventilated lung units ("Silent Spaces") and transpulmonary pressure (PL). EIT could guide PEEP selection based on optimal homogeneity of ventilation distribution.
Chest electrical impedance tomography examination, data analysis, terminology, clinical use and recommendations: consensus statement of the TRanslational EIT developmeNt stuDy group
Frerichs, I., et al. Thorax. 2017.
This consensus paper, prepared by the TREND group, provides consensus on clinical applications (neonatal, pediatric, and adult), unified terminology, and analysis methods for EIT. Additionally, it reviews all major work in thoracic EIT and provides recommendations for future development.
Imaging the Respiratory Transition at Birth: Unraveling the Complexities of the First Breaths of Life
Tingay, D.G., et al. American Journal for Respiratory and Critical Care Medicine. 2021.
Explored EIT as the first imaging modality to monitor the neonatal respiratory transition immediately after birth, providing insights into early lung function and potential implications for interventions in the delivery room.
The DELUX study: development of lung volumes during extubation of preterm infants
Plastina, L., et al. Pediatric Research. 2022.
Investigated changes in lung volumes during extubation of very preterm infants using EIT. Extubation was associated with significant changes in EELI (correlated to FRC). Re-recruitment of lung volume began immediately after initiating non-invasive ventilation.
Prolonged Continuous Monitoring of Regional Lung Function in Infants with Respiratory Failure
Becher, T.H., et al. Annals of the American Thoracic Society. 2022.
EIT allowed continuous monitoring of regional lung function in 200 neonates and infants for up to 72 hours with minimal adverse skin integrity effects. The study confirmed posture-dependent changes in ventilation distribution and their dependency on postmenstrual age.
