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Impact of continuous transcutaneous CO2 monitoring on ventilation management in preterm infants on high-frequency ventilation
Bernatzky, Agustin et al. Pediatric research. 2025
Sentec Summary: This study of 78 VLBW infants on HFV concluded that continuous tCO2 monitoring is associated with a decreased incidence of hypocapnia and hypercapnia, less blood sampling requirements, and lower incidence of IVH.
Ventilation distribution during spontaneous breathing trials predicts liberation from mechanical ventilation: the VISION study
Phoophiboon, V., et al. Critical Care. 2025
EIT evaluated regional ventilation distribution during spontaneous breathing trials in mechanically ventilated patients. Results revealed that successfully weaned patients had a reduced ventral-to-dorsal ventilation difference, while those with higher differences were more likely to fail weaning.
Electrical impedance tomography monitoring in adult ICU patients:
Scaramuzzo, G., et al. Critical Care. 2024
This review paper is the result of an expert meeting and discusses the latest recommendations and future directions in EIT acquisition, processing, and applications during both mechanically ventilated and spontaneously breathing adult ICU patients.
Deciphering Mechanisms of Respiratory Fetal-to-Neonatal Transition in Very Preterm Infants
Gaertner, V.D., et al. American Journal for Respiratory and Critical Care Medicine. 2023
Over 10,000 breaths from 33 preterm infants (26-32 weeks GA) were analyzed with Sentec EIT to characterize breathing patterns during the transition from fetal to neonatal life: tidal breathing, braking, and holding. Findings revealed that holding breaths contributed most to early lung aeration.
Initial Observations on the Effect of Repeated Surfactant Dose on Lung Volume and Ventilation in Neonatal Respiratory Distress Syndrome
Kallio, M., et al. Neonatology. 2019
This study, part of the CRADL multicenter trial, investigated the effects of repeated surfactant dosing on regional ventilation and lung volumes in preterm infants. EIT revealed that repeated surfactant dose during invasive ventilation improved oxygenation without measurable changes in EELZ.
Transmission of Oscillatory Volumes into the Preterm Lung during Noninvasive High-Frequency Ventilation
Gaertner, V.D., et al. American Journal for Respiratory and Critical Care Medicine. 2021
This randomized crossover trial of 30 infants utilizing EIT provided the first evidence that nHFOV oscillations were effectively transmitted to the lungs, with a preference for the right and non-gravity-dependent lung regions.
Lung Volume Changes in Stable Preterm Infants Weaned From Nasal CPAP to High Flow
Büchler, V.L., et al. CHEST Pulmonary. 2024.
Monitoring preterm infants with EIT illustrated that the transition from nCPAP to high flow is likely to result in a gradual reduction in EELV, accompanied by physiological responses in heart rate and oxygenation.
Lung Recruitment Assessed by Electrical Impedance Tomography (RECRUIT): A Multicenter Study of COVID-19 Acute Respiratory Distress Syndrome
Jonkman, A.H., et al. American Journal for Respiratory and Critical Care Medicine. 2023.
In this multicenter study, EIT allowed personalized PEEP setting as a compromise between recruitability and overdistension (crossing point method) in 108 COVID-19 ARDS patients.
Personalized Positive End-Expiratory Pressure in Acute Respiratory Distress Syndrome: Comparison Between Optimal Distribution of Regional Ventilation and Positive Transpulmonary Pressure
Scaramuzzo, G., et al. Critical Care Medicine. 2020.
This study compared two methods of selecting personalized PEEP in ARDS patients: EIT based on the total amount of hypoventilated lung units ("Silent Spaces") and transpulmonary pressure (PL). EIT could guide PEEP selection based on optimal homogeneity of ventilation distribution.
Chest electrical impedance tomography examination, data analysis, terminology, clinical use and recommendations: consensus statement of the TRanslational EIT developmeNt stuDy group
Frerichs, I., et al. Thorax. 2017.
This consensus paper, prepared by the TREND group, provides consensus on clinical applications (neonatal, pediatric, and adult), unified terminology, and analysis methods for EIT. Additionally, it reviews all major work in thoracic EIT and provides recommendations for future development.
